Assessment of needle tip geometry during infusions into a brain phantom gel

  • Gustavo Orozco University of Eastern Finland
  • Fernando Casanova Universidad del Valle
  • Jose Jaime Garcia Universidad del Valle
Palabras clave: brain phantom gel, backflow, convection-enhanced delivery, drug infusion, needle insertion.

Resumen

Convection-enhanced delivery (CED) is a promising method to deliver therapeutic drugs directly into the brain that has shown limited efficacy, mainly attributed to backflow, in which the infused drug flows back along the needle track rather than forward into tissue. This study evaluates the effect of sharp and blunt needle tips on backflow length under different flow rates via CED. Infusions were performed in a transparent 0.6% (w/v) brain phantom agarose hydrogel. Backflow length was significantly higher using sharp-tip needles for higher flow rates. No significant differences were observed between tip shapes for lower flow rates. In conclusion, sharp-tip needles present limitations for higher flow rates, which are needed to deliver more drug during shortest times.

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Publicado
2020-12-17
Cómo citar
Orozco, G., Casanova, F., & Garcia, J. (2020). Assessment of needle tip geometry during infusions into a brain phantom gel. Scientia Et Technica, 25(4), 616-620. https://doi.org/10.22517/23447214.21511
Sección
Bioingeniería