Assessment of needle tip geometry during infusions into a brain phantom gel: Evaluación de la geometría de la punta de la aguja durante infusiones en gel de agarosa

Gustavo Alejandro Orozco Grajales; Fernando Casanova García; Jose Jaime García Álvarez

doi:10.22517/23447214.21511

Assessment of needle tip geometry during infusions into a brain phantom gel

Evaluación de la geometría de la punta de la aguja durante infusiones en gel de agarosa

Authors

Gustavo Alejandro Orozco Grajales University of Eastern Finland https://orcid.org/0000-0002-1054-7937
Fernando Casanova García Universidad del Valle https://orcid.org/0000-0002-3146-2027
Jose Jaime García Álvarez Universidad del Valle https://orcid.org/0000-0003-2580-805X

DOI:

https://doi.org/10.22517/23447214.21511

Keywords:

brain phantom gel, backflow, convection-enhanced delivery, drug infusion, needle insertion.

Abstract

Convection-enhanced delivery (CED) is a promising method to deliver therapeutic drugs directly into the brain that has shown limited efficacy, mainly attributed to backflow, in which the infused drug flows back along the needle track rather than forward into tissue. This study evaluates the effect of sharp and blunt needle tips on backflow length under different flow rates via CED. Infusions were performed in a transparent 0.6% (w/v) brain phantom agarose hydrogel. Backflow length was significantly higher using sharp-tip needles for higher flow rates. No significant differences were observed between tip shapes for lower flow rates. In conclusion, sharp-tip needles present limitations for higher flow rates, which are needed to deliver more drug during shortest times.

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Published

2020-12-30

How to Cite

Orozco Grajales, G. A., Casanova García, F., & García Álvarez, J. J. (2020). Assessment of needle tip geometry during infusions into a brain phantom gel: Evaluación de la geometría de la punta de la aguja durante infusiones en gel de agarosa. Scientia Et Technica, 25(4), 616–620. https://doi.org/10.22517/23447214.21511

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Issue

Vol. 25 No. 4 (2020)

Section

Bioingeniería

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