Enfermedad cardiovascular. Una mirada en función del género: revisión de literatura
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https://doi.org/10.22517/25395203.25260Palabras clave:
Enfermedades cardiovasculares, mujeres, prevención primaria, síndrome coronario agudoResumen
La enfermedad cardiovascular se ha constituido como la principal causa de muerte en hombres y mujeres en Colombia y a nivel mundial. Su prevalencia continúa siendo importante, pues en los últimos años no han existido cambios notables en las tendencias preventivas o de tratamiento. Sin embargo, en la actualidad la relación con el género se ha venido consolidando, por lo que constituye actualmente un rol relevante, a través del cual se han dilucidado diferencias epidemiológicas, fisiopatológicas y etiológicas entre hombres y mujeres, que podrían potencialmente marcar diferencias en el diagnóstico, tratamiento y desenlaces duros. Este artículo tiene como objetivo describir los antecedentes y diferentes factores que se han estudiado en la enfermedad cardiovascular y su relación con el género, especialmente enfocado en mujeres
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Mc Namara K, Alzubaidi H, Jackson JK. Cardiovascular disease as a leading cause of death: how are pharmacists getting involved? Integr Pharm Res Pract. 2019; 8: 1–11.
Lucia D, Diaz O, Andrés C, Charry A, Dary L, Solano B, et al. Propuesta de intervención del problema de salud pública de las enfermedades Cardiovasculares (ECV) en el Departamento del Putumayo. Putumayo: 2020.
Vaina S. Coronary artery disease in women: From the yentl syndrome to contemporary treatment. World J Cardiol. 2015; 7(1): 10.
James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 Diseases and Injuries for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017 [Internet]. Lancet. . 2018 Nov 10 [cited 2022 Apr 14]; 392(10159): 1789–858.
Healy B. The Yentl Syndrome. N Engl J Med. 1991; 325(4): 274–6.
Ayanian JZ, Epstein AM. Differences in the use of procedures between women and men hospitalized for coronary heart disease [Internet]. N Engl J Med.. 1991 Jul 25 [cited 2022 Nov 21]; 325(4): 221–5.
Leonard EA, Marshall RJ. Cardiovascular Disease in Women. Prim Care - Clin Off Pract. 2018; 45(1): 131–41.
Kandasamy S, Anand SS. Cardiovascular Disease Among Women From Vulnerable Populations: A Review. Can J Cardiol. 2018; 34(4): 450–7.
Cenko E, van der Schaar M, Yoon J, Manfrini O, Vasiljevic Z, Vavlukis M, et al. Sex-Related Differences in Heart Failure After ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol. 2019 Nov 12; 74(19): 2379–89.
Lee PY, Alexander KP, Hammill BG, Pasquali SK, Peterson ED. Representation of elderly persons and women in published randomized trials of acute coronary syndromes. J Am Med Assoc. 2001; 286(6): 708–13.
Balla S, Gomez SE, Rodriguez F. Disparities in Cardiovascular Care and Outcomes for Women From Racial/Ethnic Minority Backgrounds. Curr Treat Options Cardiovasc Med. 2020; 22(12).
Revuelta JM, Alconero-Camarero AR. Corazón de mujer. Cirugía Cardiovasc. 2020 Mar 1; 27(2): 39–41.
Prabhavathi K, Tamarai Selvi K, Poornima KN, Sarvanan A. Role of Biological Sex in Normal Cardiac Function and in its Disease Outcome – A Review [Internet]. J Clin Diagn Res. 2014 [cited 2022 Nov 28]; 8(8): BE01.
Kittnar O, Kittnar O. Selected Sex Related Differences in Pathophysiology of Cardiovascular System. Physiol.Res. 2020 [cited 2023 Jan 2]; 69: 21-31.
Dearing C, Handa RJ, Myers B. Sex differences in autonomic responses to stress: implications for cardiometabolic physiology [Internet]. Am J Physiol Endocrinol Metab. 2022 Sep 1 [cited 2023 Jan 2]; 323(3): E281–9.
Romero-Becerra R, Santamans AM, Folgueira C, Sabio G. p38 MAPK Pathway in the Heart: New Insights in Health and Disease [Internet]. Int J Mol Sci . 2020 Oct 8 [cited 2023 Jan 2];21(19): 7412.
Chen P, Li B, Ou-Yang L. Role of estrogen receptors in health and disease. Front Endocrinol (Lausanne). 2022 Aug 18; 13: 1918.
van Esdonk MJ, Burggraaf J, van der Graaf PH, Stevens J. Model informed quantification of the feed-forward stimulation of growth hormone by growth hormone-releasing hormone [Internet]. Br J Clin Pharmacol . 2020 Aug 1 [cited 2023 Jan 2]; 86(8): 1575–584.
Anand SS, Islam S, Rosengren A, Franzosi MG, Steyn K, Yusufali AH, et al. Risk factors for myocardial infarction in women and men: insights from the INTERHEART study [Internet]. Eur Heart J. 2008 Apr 1 [cited 2022 Nov 21]; 29(7): 932–940.
Ghinassi B, Di Baldassarre A, Crescioli C. Biomolecules and Cardiovascular Diseases in Women [Internet]. Biomolecules. 2022 Dec 1 [cited 2023 Jan 2];12(12).
Bairey Merz CN, Ramineni T, Leong D. Sex-specific risk factors for cardiovascular disease in women-making cardiovascular disease real. Curr Opin Cardiol. 2018;33(5):500–5.
Maas AHEM, Appelman YEA. Gender differences in coronary heart disease. Netherlands Hear J. 2010; 18(12): 598–603.
Cho L, David M, Elgendy I, Epps K, Lindley K, Mehta PK, et al. Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020; 75(20): 2602–618.
Peters SAE, Huxley RR, Woodward M. Diabetes as risk factor for incident coronary heart disease in women compared with men: A systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events. Diabetologia. 2014; 57(8):1542–551.
Mehta LS, Beckie TM, DeVon HA, Grines CL, Krumholz HM, Johnson MN, et al. Acute Myocardial Infarction in Women : A Scientific Statement from the American Heart Association. Circulation. 2016; 133(9): 916–947.
Montarello N, Chan WP (Alicia). Coronary artery disease in women. Aust Prescr [Internet]. 2022 Nov 30 [cited 2023 Jan 2]; 45(6): 193.
Silva FC da, Araújo BJ de, Cordeiro CS, Arruda VM, Faria BQ, Guerra JFDC, et al. Endothelial dysfunction due to the inhibition of the synthesis of nitric oxide: Proposal and characterization of an in vitro cellular model. Front Physiol. 2022 Nov 17; 13: 2413.
Sanghavi M, Gulati M. Cardiovascular Disease in Women: Primary and Secondary Cardiovascular Disease Prevention. Obstet Gynecol Clin North Am. 2016; 43(2): 265–285.
Bucciarelli V, Caterino AL, Bianco F, Caputi CG, Salerni S, Sciomer S, et al. Depression and cardiovascular disease: The deep blue sea of women’s heart. Trends Cardiovasc Med. 2020; 30(3): 170–6.
Scott-Storey KA, Hodgins M, Wuest J. Modeling lifetime abuse and cardiovascular disease risk among women. BMC Cardiovasc Disord. 2019; 19(1): 1–14.
Mattina GF, Van Lieshout RJ, Steiner M. Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events. Ther Adv Cardiovasc Dis. 2019; 13: 1–26.
Kim JE, Chang JH, Jeong MJ, Choi J, Park JY, Baek C, et al. A systematic review and meta-analysis of effects of menopausal hormone therapy on cardiovascular diseases. Sci Rep. 2020; 10(1): 1–13.
Keck C, Taylor M. Emerging Research on the Implications of Hormone Replacement Therapy on Coronary Heart Disease. Curr Atheroscler Rep. 2018; 20(12): 18–21.
Sueldo MA del, Rivera MAM, Sánchez-Zambrano MB, Zilberman J, Múnera-Echeverri AG, Paniagua M, et al. Guía de práctica clínica de la Sociedad Interamericana de Cardiología sobre prevención primaria de enfermedad cardiovascular en la mujer [Internet]. Arch Cardiol México. 2022 Jun 1 [cited 2022 Nov 22]; 92: 1–68.
Agarwala A, Michos ED, Samad Z, Ballantyne C, Virani SS. The Use of Sex-Specific Factors in the Assessment of Women’s Cardiovascular Risk. Circulation. 2020; 141(7): 592–9.
Maffei S, Guiducci L, Cugusi L, Cadeddu C, Deidda M, Gallina S, et al. Women-specific predictors of cardiovascular disease risk - new paradigms. Int J Cardiol. 2019; 286:190–7.
Gunning MN, Meun C, Van Rijn BB, Daan NMP, Van Lennep JER, Appelman Y, et al. The cardiovascular risk profile of middle age women previously diagnosed with premature ovarian insufficiency: A case-control study. PLoS One. 2020; 15(3):1–17.
Young L, Cho L. Unique cardiovascular risk factors in women. Heart. 2019; 105(21):1656–660.
Kurmann RD, Mankad R. Atherosclerotic Heart Disease in Women With Autoimmune Rheumatologic Inflammatory Conditions. Can J Cardiol. 2018; 34(4): 381–9.
Geraghty L, Figtree GA, Schutte AE, Patel S, Woodward M, Arnott C. Cardiovascular Disease in Women: From Pathophysiology to Novel and Emerging Risk Factors. Hear Lung Circ. 2021; 30(1): 9–17.
Anagnostis P, Lambrinoudaki I, Stevenson JC, Goulis DG. Menopause-associated risk of cardiovascular disease [Internet]. Endocr Connect. 2022 Apr 4 [cited 2023 Jan 2]; 11(4).
Undas A. Impact factor 2021 of Polish Archives of Internal Medicine. Polish Arch Intern Med. 2022 Aug 22; 132(7–8).
Vogel B, Acevedo M, Appelman Y, Bairey Merz CN, Chieffo A, Figtree GA, et al. The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030 [Internet]. Lancet. 2021 Jun 19 [cited 2022 Nov 28]; 397(10292): 2385–438.
Shehab A, Bhagavathula AS, Alhabib KF, Ullah A, Suwaidi J Al, Almahmeed W, et al. Age-Related Sex Differences in Clinical Presentation, Management, and Outcomes in ST-Segment–Elevation Myocardial Infarction: Pooled Analysis of 15 532 Patients From 7 Arabian Gulf Registries [Internet]. J Am Heart Assoc. 2020 Feb 18 [cited 2022 Nov 28]; 9(4).
Kim HO, Kim CJ, Kim W, Cho JM, Soeda T, Takano M, et al. Relative risk of plaque erosion among different age and sex groups in patients with acute coronary syndrome. J Thromb Thrombolysis. 2020; 49(3): 352–9.
Vogel B, Goel R, Kunadian V, Kalkman DN, Chieffo A, Appelman Y, et al. Residual angina in female patients after coronary revascularization [Internet]. Int J Cardiol. 2019 Jul 1 [cited 2022 Nov 28]; 286: 208–213.
Pagidipati NJ, Hemal K, Coles A, Mark DB, Dolor RJ, Pellikka PA, et al. Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease. J Am Coll Cardiol. 2016 Jun 7; 67(22): 2607–616.
Pagidipati NJ, Peterson ED. Acute coronary syndromes in women and men. Nat Rev Cardiol. 2016; 13(8): 471–480.
Schneider B, Sechtem U. Influence of Age and Gender in Takotsubo Syndrome. Heart Fail Clin. 2016; 12(4): 521–530.
Sharedalal P, Aronow WS. A review of diagnosis, etiology, assessment, and management of patients with myocardial infarction in the absence of obstructive coronary artery disease [Internet]. Hosp Pract (1995). 2021 Feb 1 [cited 2023 Jan 2]; 49(1): 12–21.
Review on Spontaneous Coronary Artery Dissection - American College of Cardiology [Internet]. [cited 2023 Jan 2]. Available from: https://www.acc.org/latest-in-cardiology/ten-points-to-remember/2020/08/19/12/09/spontaneous-coronary-artery-dissection
Tweet MS, Kok SN, Hayes SN. Spontaneous coronary artery dissection in women: What is known and what is yet to be understood. Clin Cardiol. 2018; 41(2): 203–210.
Rehan R, Weaver J, Yong A. Coronary Vasospastic Angina: A Review of the Pathogenesis, Diagnosis, and Management [Internet]. Life. 2022 Aug 1 [cited 2023 Jan 2]; 12(8).
Lee DH, Park TK, Seong CS, Gwag H Bin, Lim AY, Oh MS, et al. Gender differences in long-term clinical outcomes and prognostic factors in patients with vasospastic angina. Int J Cardiol. 2017; 249: 6–11.
Kunadian V, Chieffo A, Camici PG, Berry C, Escaned J, Maas AHEM, et al. An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with european society of cardiology working group on coronary pathophysiology & microcirculation endorsed by coronary vasomotor disorders international study group. EuroIntervention. 2021; 16(13):1049–069.
Reynolds HR, Shaw LJ, Min JK, Spertus JA, Chaitman BR, Berman DS, et al. Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia: Secondary Analysis of the ISCHEMIA Randomized Clinical Trial [Internet]. JAMA Cardiol. 2020 Jul 1 [cited 2022 Nov 28]; 5(7):773–786.
Gulati M, Cooper-DeHoff RM, McClure C, Johnson BD, Shaw LJ, Handberg EM, et al. Adverse Cardiovascular Outcomes in Women With Nonobstructive Coronary Artery Disease: A Report From the Women’s Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project [Internet]. Arch Intern Med. 2009 May 11 [cited 2022 Nov 28];169(9): 843–850.
Soleymani M, Masoudkabir F, Shabani M, Vasheghani-Farahani A, Behnoush AH, Khalaji A. Updates on Pharmacologic Management of Microvascular Angina [Internet]. Cardiovasc Ther . 2022 Oct 25 [cited 2023 Jan 2]; 2022:1–19.
Min JK, Dunning A, Lin FY, Achenbach S, Al-Mallah M, Budoff MJ, et al. Age-and Sex-Related Differences in All-Cause Mortality Risk Based on Coronary Computed Tomography Angiography Findings Results From the International Multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) of 23,854 Patients Without Known Coronary Artery Disease. 2011;
Luu JM, Wei J, Shufelt CL, Asif A, Tjoe B, Theriot P, et al. Clinical Practice Variations in the Management of Ischemia With No Obstructive Coronary Artery Disease [Internet]. J Am Heart Assoc]. 2022 Oct 1 [cited 2023 Jan 2]; 11(19).
Ferencik M, Mayrhofer T, Bittner DO, Emami H, Puchner SB, Lu MT, et al. Use of High-Risk Coronary Atherosclerotic Plaque Detection for Risk Stratification of Patients With Stable Chest Pain: A Secondary Analysis of the PROMISE Randomized Clinical Trial [Internet]. JAMA Cardiol. 2018 Feb 1 [cited 2022 Nov 22]; 3(2):144–152.
Reynolds HR, Maehara A, Kwong RY, Sedlak T, Saw J, Smilowitz NR, et al. Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women. Circulation. 2021; 143(7): 624–640.
Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio ALP, et al. CURRENT OPINION ESC working group position paper on myocardial infarction with non-obstructive coronary arteries on behalf of the WG on Cardiovascular Pharmacotherapy. [cited 2022 Nov 28]; Available from: https://academic.oup.com/eurheartj/article/38/3/143/2967570
Parvand M, Cai L, Ghadiri S, Humphries KH, Starovoytov A, Daniele P, et al. One-Year Prospective Follow-up of Women With INOCA and MINOCA at a Canadian Women’s Heart Centre [Internet]. Can J Cardiol. 2022 Oct 1 [cited 2022 Nov 28]; 38(10):1600–610.
Gudnadottir GS, Andersen K, Thrainsdottir IS, James SK, Lagerqvist B, Gudnason T. Gender differences in coronary angiography, subsequent interventions, and outcomes among patients with acute coronary syndromes. Am Heart J. 2017; 191: 65–74.
Sathyamurthy I, Sengottuvelu G. Can OCT change the therapeutic strategy in ACS due to plaque erosion? [Internet]. Indian Heart J. 2021 May 1 [cited 2023 Jan 2]; 73(3): 259–263.
Crea F, Vergallo R. Plaque erosion: Towards precision medicine in acute coronary syndromes. Int J Cardiol. 2019; 288: 22–4.
Jia H, Dai J, Hou J, Xing L, Ma L, Liu H, et al. Effective anti-thrombotic therapy without stenting: Intravascular optical coherence tomography-based management in plaque erosion (the EROSIONstudy). Eur Heart J. 2017; 38(11): 792–800.
Xing L, Yamamoto E, Sugiyama T, Jia H, Ma L, Hu S, et al. EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography-Based Management in Plaque Erosion): A 1-Year Follow-Up Report. Circ Cardiovasc Interv. 2017; 10(12): 1–8.
Okunrintemi V, Valero-Elizondo J, Patrick B, Salami J, Tibuakuu M, Ahmad S, et al. Gender differences in patient-reported outcomes among adults with atherosclerotic cardiovascular disease. J Am Heart Assoc. 2018; 7(24).
Solimene MC. Coronary heart disease in women: A challenge for the 21st century. Clinics. 2010; 65(1): 99–106.
Walli-Attaei M, Joseph P, Rosengren A, Chow CK, Rangarajan S, Lear SA, et al. Variations between women and men in risk factors, treatments, cardiovascular disease incidence, and death in 27 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. Lancet. 2020; 396(10244): 97–109.
Hyun K, Negrone A, Redfern J, Atkins E, Chow C, Kilian J, et al. Gender Difference in Secondary Prevention of Cardiovascular Disease and Outcomes Following the Survival of Acute Coronary Syndrome [Internet]. Hear Lung Circ. 2021 [cited 2022 Nov 28]; 30:121–7.
Cífková R. Gender differences in secondary prevention of coronary heart disease: Far from closing the gap [Internet]. Int J Cardiol. 2022 May 15 [cited 2022 Nov 28]; 355: 52–3.
Khan SU, Khan MZ, Raghu Subramanian C, Riaz H, Khan MU, Lone AN, et al. Participation of Women and Older Participants in Randomized Clinical Trials of Lipid-Lowering Therapies: A Systematic Review. JAMA Netw open. 2020; 3(5): e205202.
Garcia M, Mulvagh SL, Merz CNB, Buring JE, Manson JAE. Cardiovascular disease in women: Clinical perspectives. Circ Res. 2016; 118(8): 1273–293.
Byrne P, Cullinan J, Smith A, Smith SM. Statins for the primary prevention of cardiovascular disease: An overview of systematic reviews. BMJ Open. 2019; 9(4).
García M. Factores de riesgo cardiovascular desde la perspectiva de sexo y género. Rev Colomb Cardiol. 2018; 25(S1): 8–12.
Trejo MC, Medina H, Rojas CA. Utility of coronary calcium score in women. Rev Colomb Cardiol. 2018; 25:73–83.
Kelkar AA, Schultz WM, Khosa F, Schulman-Marcus J, O’Hartaigh BWJ, Gransar H, et al. Long-Term Prognosis after Coronary Artery Calcium Scoring among Low-Intermediate Risk Women and Men. Circ Cardiovasc Imaging [Internet]. 2016 Apr 1 [cited 2022 Nov 22]; 9(4).
Grundy SM, Vega GL. Statin therapy for primary prevention in women: What is the role for coronary artery calcium? J Clin Lipidol. 2022 Jul 1; 16(4): 376–382.
Smith JR, Thomas RJ, Bonikowske AR, Hammer SM, Olson TP. Sex Differences in Cardiac Rehabilitation Outcomes. Circ Res. 2022 Feb 18; 130(4):552–565.
Colbert JD, Martin BJ, Haykowsky MJ, Hauer TL, Austford LD, Arena RA, et al. Cardiac rehabilitation referral, attendance and mortality in women. Eur J Prev Cardiol [Internet]. 2015 Aug 1 [cited 2022 Nov 28]; 22(8): 979–986.
Rjan Ekblom O¨, Sa Cider A˚, Hambraeus K, Bäck M, Leosdottir M, Lö Nn A, et al. Participation in exercise-based cardiac rehabilitation is related to reduced total mortality in both men and women: results from the SWEDEHEARTregistry. [cited 2022 Nov 28];
Stock EO, Redberg R. Cardiovascular Disease in Women. Curr Probl Cardiol. 2012; 37(11): 450–526.
Benschop L, Duvekot JJ, Roeters Van Lennep JE. Future risk of cardiovascular disease risk factors and events in women after a hypertensive disorder of pregnancy. Heart. 2019; 105(16): 1273–8.
Arnott C, Patel S, Hyett J, Jennings G, Woodward M, Celermajer DS. Women and Cardiovascular Disease: Pregnancy, the Forgotten Risk Factor. Hear Lung Circ. 2020; 29(5): 662–7.
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