Extractos vegetales con actividad sobre cepas mutadas de saccharomyces cerevisiae con deficiencia en el mecanismo de reparacion del adn


Authors

  • Jaime Niño O.
  • Paola A. Morales
  • Juliana Batero
  • Yaned M. Correa N.
  • Oscar M. Mosquera M.

Abstract

Ciento treinta y ocho extractos obtenidos de plantas pertenecientes a las familias botánicas Asteraceae, Euphorbiaceae, Melastomataceae, Podocarpaceae, Rubiaceae y Solanaceae recolectadas en reservas naturales de la Ecorregión del Eje Cafetero (EEC) fueron evaluadas contra cepas de la levadura Saccharomyces cerevisiae RS 322N, R52Y y RS 321 por el método de difusión en agar, con el propósito de identificar nuevos extractos bioactivos que dañen el ADN y/o que inhiban las topoisomerasas I o II. Los extractos metanólicos de las especies pertenecientes a la familia Solanaceae: Browallia speciosa, Cestrum olivaceum y Solanum brevifolium mostraron selectividad para el ensayo de la levadura Saccharomyces cerevisiae mutada, presentando actividad como inhibidor de la topoisomerasa I. Adicionalmente, el extracto de diclorometano deSolanum deflexiflorum perteneciente a la misma familia presentó actividad inhibidora de la topoisomerasa II.

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Published

2007-01-05

How to Cite

Niño O., J., Morales, P. A., Batero, J., Correa N., Y. M., & Mosquera M., O. M. (2007). Extractos vegetales con actividad sobre cepas mutadas de saccharomyces cerevisiae con deficiencia en el mecanismo de reparacion del adn. Scientia Et Technica, 1(33). Retrieved from https://revistas.utp.edu.co/index.php/revistaciencia/article/view/6065

Issue

Vol. 1 No. 33 (2007)

Section

Ciencias Básicas

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