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Diagnosis of congenital Chagas disease: Relevant aspects


Authors

DOI:

https://doi.org/10.22517/25395203.25093

Keywords:

Chagas disease, molecular biology, diagnosis, PCR, Trypanosoma cruzi

Abstract

Introduction: This article describes relevant aspects surrounding congenital Chagas disease, such as epidemiology, symptomatology, review of clinical cases, and diagnostic techniques.

Methods: A review of the literature was carried out through bibliographic databases such as PubMed, Science direct, Scopus, Plos One, SciELO, having as inclusion criteria articles or publications between January 2013 and January 2022 in Spanish and English.

Results:  It was determined that the prevalence of congenital Chagas disease is still a public health problem in endemic and non-endemic areas, and maternal serology is essential for timely follow-up of cases.

Conclusions: Current diagnostic follow-ups differ in endemic countries and screening is being applied in non-endemic areas where women from areas of active transmission of Chagasdisease migrate.

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Author Biographies

Dayana Sofía Torres Martínez, Universidad de Boyacá

Bacterióloga y Laboratorista clínica

Docente investigadora

John Jaime Quimbaya Ramírez, Universidad de Santander

Médico Veterinario

Especialista en Práctica Clínica de pequeños animales con énfasis en Anestesia

M.Sc. Investigación en Enfermedades Infecciosas

Ángela Liliana Monroy-Díaz, Universidad de Boyacá

Directora de Programa de Bacteriología y Laboratorio clínico

Bacterióloga y Laboratorista clínica

Especialista en Gerencia de instituciones de Salud

Magíster en Investigación en enfermedades infecciosas

Magíster en Dirección estratégica

 

References

Subdirección de Vigilancia y Control en Salud Pública. Guía protocolo para la vigilancia en salud pública de Chagas. Ministerio de salud. Disponible en: https://www.minsalud.gov.co/Documents/Salud%20P%C3%BAblica/Ola%20invernal/Protocolo%20Chagas.pdf

Cevallos A.M, Hernández R. Chagas Disease: Pregnancy and Congenital Transmission. Biomed Res Int. 2014; 401864. DOI: 10.1155/2014/401864

Cucunubá Z.M, Valencia C.A, Puerta C.J, Sosa S., Torrico F., Cortés J.A, et al. Primer consenso colombiano sobre Chagas congénito y orientación clínica a mujeres en edad fértil con diagnóstico de Chagas. Infectio. 2014;50-65. DOI: 10.1016/j.infect.2013.12.001

Freitas K.C, Andrade F.A, Bavia L., Damasceno F.S, Holsbach M., Messias I.J, et al. Chagas Disease: From Discovery to a Worldwide Health Problem. Front Public Health. 2019; 7: 166. DOI: 10.3389/fpubh.2019.00166

Carlier Y, Estani SS, Luquetti AO, Buekens P. Congenital Chagas disease: an update. Mem Inst Oswaldo Cruz. 2015; 110(3): 363-368. DOI: 10.1590/0074-02760140405

Padilla JA, Gallego M, Schijman AG, Gascon J. Molecular diagnostics for Chagas disease: up to date and novel methodologies. Expert Review of Molecular Diagnostics. 2017. DOI: 10.1080/14737159.2017.1338566

Messenger LA, Bern C. Congenital Chagas disease: current diagnostics, limitations and future perspectives. Curr Opin Infect Dis. 2018; 31 (5): 415-421. DOI: 10.1097/QCO.0000000000000478

Edwards MS, Montgomery SP. Chagas Disease: Implementation of Screening to Benefit Mother and Infant. Clinics in Perinatology. 2021; 48(2): 331-342. DOI: https://doi.org/10.1016/j.clp.2021.03.013

Edwards MS, Stimpert KK, Bialek SR, Montgomery SP. Evaluation and Management of Congenital Chagas Disease in the United States. J Pediatric Infect Dis Soc. 2019; 8(5): 461-469. DOI: 10.1093/jpids/piz018.

Marcus R., Henao A.F, Nolan M., Livingston E., Klotz S.A, Gilman R.H, et al. Recognition and screening for Chagas disease in the USA. Ther Adv Infect Dis. 2021; 8: 20499361211046086. DOI: 10.1177/20499361211046086

Livingston E.G, Duggal R., Dotters S. Screening for Chagas Disease during Pregnancy in the United States—A Literature Review. Trop Med Infect Dis. 2021; 6(4): 202. DOI: 10.3390/tropicalmed6040202

Chakravarti I., Schaeubinger M.M, Ruiz A., Briones C., Fernández E.A, Villanueva C.C, et al. Chagas Disease in Pregnant Women from Endemic Regions Attending the Hospital General de Mexico, Mexico City. Trop Med Infect Dis. 2022; 7(1): 8. DOI: 10.3390/tropicalmed7010008

Restrepo Zambrano M, Rouset F, Carrasco OF, Echeverría Murillo D, Costales JA, Breniére SF. Congenital Chagas Disease in the Ecuadorian Amazon: Maternal Screening at Delivery and Evaluation of Risk Factors Associated with Vector Exposure. Am J Trop Med Hyg. 2019; 101(6):1350-1358. DOI: 10.4269/ajtmh.19-0340

Bern C., Messenger L.A, Whitman A., Maguire J.H. Chagas Disease in the United States: a Public Health Approach. Clin Microbiol Rev. 2020; 33(1): e00023-19. DOI: 10.1128/CMR.00023-19

Santana K.H, Rodrigues L.G, De Castro D.B, Pereira M. Epidemiology of Chagas disease in pregnant women and congenital transmission of Trypanosoma cruzi in the Americas: systematic review and meta-analysis. Trop Med Int Health. 2020 ;25(7):752-763. DOI: 10.1111/tmi.13398.

Suescún S.H, Medina M.I, Murcia N.A, Forero S.M. Infección por Trypanosoma Cruzi en donantes de un banco de sangre del departamento Boyacá, Colombia. Rev. Méd. Risaralda 2021; 27 (1): 27-33. DOI: 10.22517/25395203.24601

Benatar AF, Danesi E, Besuschio SA, Bortolotti S, Cafferata ML, Ramíeez JC, et al. Prospective multicenter evaluation of real time PCR Kit prototype for early diagnosis of congenital Chagas disease. EBiomMedicine. 2021; 69: 103450. DOI: 10.1016/j.ebiom.2021.103450

Bua J, Volta BJ, Perrone AE, Scollo K, Velázquez EB, Ruiz AM, et al. How to Improve the Early Diagnosis of Trypanosoma cruzi Infection: Relationship between Validated Conventional Diagnosis and Quantitative DNA Amplification in Congenitally Infected Children. PLoS Negl Trop Dis. 2013; 7(10): e2476. DOI: https://doi.org/10.1371/journal.pntd.0002476

Buekens P, Cafferata ML, Alger J, Althabe F, Belizán JM, Bustamante N, et al. Congenital Transmission of Trypanosoma cruzi in Argentina, Honduras, and Mexico: An Observational Prospective Study. Am J Trop Med HYG. 2018; 98(2): 478-485. DOI: 10.4269/ajtmh.17-0516

Iglesias L., Barja M.R, Boquete T., Benito A., Jordan B., Hernández T.B. Mapping health behaviour related to Chagas diagnosis in a non-endemic country: Application of Andersen’s Behavioural Model. PLOS ONE 17(1): e0262772. DOI: https://doi.org/10.1371/journal.pone.0262772

Subprograma nacional de promoción, prevención y control de la Enfermedad de Chagas. Plan de interrupción de la transmisión vectorial intradomiciliaria de Trypanosoma cruzi por Rhodnius prolixus en 34 municipios priorizados de colombia, 2019. 2020:1- 403. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/plan-interrupcion-transmisionn-cruzi-prolixus-colombia2019.pdf

Monroy-Díaz A., Rodríguez-Niño S., Suescún-Carrero S.H, Ramírez-López L. Seroprevalencia de infección por Trypanosoma cruzi y factores asociados en Miraflores, Boyacá, Colombia. Revista Investig Salud Univ Boyacá. 2018;5:(1):31-47. DOI: https://doi.org/10.24267/23897325.284

Volta B, Russomando G, Bustos PL, Scollo K, Rissio AM, Sánchez Z, et al. Diagnosis of congenital Trypanosoma cruzi infection: A serologic test using Shed Acute Phase Antigen (SAPA) in mother–child binomial samples. Acta trópica. 2015;31-37. DOI: https://doi.org/10.1016/j.actatropica.2015.03.026

Martínez Ortiz, A., et al. "Enfermedad de Chagas neonatal de transmisión vertical en países no endémicos: El uso de la PCR en el diagnóstico: ventajas sobre técnicas convencionales." Anales del Sistema Sanitario de Navarra. Vol. 36. No. 1. Gobierno de Navarra. Departamento de Salud, 2013.

Parra G, Oliveros H, Hotez P, Motoa G, Paredes CF, Henao Martínez AF. In Search of Congenital Chagas Disease in the Sierra Nevada de Santa Marta, Colombia. Am J Trop Med Hyg.2019; 101 (3): 482-483. DOI: 10.4269/ajtmh.19-0110

Páez MS. Factores de riesgo y prevención primaria de la enfermedad de Chagas congénito. Universidad de Murcia 2017. Available in: https://digitum.um.es/digitum/bitstream/10201/55216/1/Marina%20Sim%C3%B3n%20P%C3%A1ez%20Tesis%20Doctoral.pdf

Balouz V., Agüero F., Buscaglia C.A. Chapter One - Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps. Advances in Parasitology. 2017; 97: 1-45. DOI: https://doi.org/10.1016/bs.apar.2016.10.001

Mejía-Jaramillo A.M, Agudelo-Uribe L.A, Dib J.C, Ortíz S., Solari A., Triana-Chávez O. Genotyping of Trypanosoma cruzi in a hyper-endemic area of Colombia reveals an overlap among domestic and sylvatic cycles of Chagas disease. Parasit Vectors. 2014; 21 (7):108. DOI: 10.1186/1756-3305-7-108.

Messenger LA, Gilman RH, Verstegui M, Cardenas GC, Sanchez G, Valencia E, Sancgez L, et al. Toward Improving Early Diagnosis of Congenital Chagas Disease in an Endemic Setting. Clin Infect Dis. 2017; 65(2): 268-275. DOI: 10.1093/cid/cix277

Carlier Y, Altcheh J, Angheben A, Freilij H, Luquetti AO, Schijman AG, et al. Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women. Plos Negl Trop Dis. 2019; 0007694. DOI: 10.1371/journal.pntd.0007694.

Abras A, Ballart C, Llovet Teresa, Roig Carme, Gutiérrez C, Tebar S, et al. Introducing automation to the molecular diagnosis of Trypanosoma cruzi infection: A comparative study of sample treatments, DNA extraction methods and real-time PCR assays. Plos One. 2018; 0195738. DOI: 10.1371/journal.pone.0195738

Manrique-Abril F., Ospina J.M, Herrera G., Florez A.C, Pavia P.X, Montilla M., et al. Diagnóstico de enfermedad de Chagas en mujeres embarazadas y recién nacidos de Moniquirá y Miraflores, Boyacá, ColombiaDiagnosis of Chagas disease in pregnant women and newborns in Moniquirá and Miraflores, Boyacá, Colombia. Infectio. 2013; 17 (1): 28-34. DOI: https://doi.org/10.1016/S0123-9392(13)70045-6

López R, Norman FF, Bern C. 103- American Trypanosomiasis. Hunter's Tropical Medicine and Emerging Infectious Diseases. 2020: 762-775. DOI: https://doi.org/10.1016/B978-0-323-55512-8.00103-4

Avila- Arzanegui O., Liendo- Arenaza P., Martínez-Indart L., Martinez- Astorkiza T., Pocheville- Guruceta M.I, Egurbide- Arberas M.V. Prevalencia de la infección por Trypanosoma cruzi y transmisión vertical en mujeres gestantes latinoamericanas en un área de salud de Vizcaya. Enferm Infecc Microbiol Clín. 2013; 31 (4): 210-2016. DOI: https://doi.org/10.1016/j.eimc.2012.01.029

Rendell V.R, Gilman R.H, Valencia E., Cardenas G.G, Verastegui M., Sanchez L., et al. Trypanosoma cruzi-Infected Pregnant Women without Vector Exposure Have Higher Parasitemia Levels: Implications for Congenital Transmission Risk. PLoS ONE. 2015; 10(3): e0119527. DOI: https://doi.org/10.1371/journal.pone.0119527

Sandoval Martínez D.K, Jaimes Sanabria M.Z, Jiménez Vargas F.L. Trasmisión vertical de la enfermedad de Chagas: reporte de caso. Ginecol.obstet. 2020; 88(4). DOI: https://doi.org/10.24245/gom.v88i4.3607

Imai K., Maeda T., Sayama Y., Mikita K., Fujikura Y., Misawa K., et al. Transmisión de madre a hijo de la enfermedad de Chagas congénita, Japón. Emergente Infect Dis. 2014; 20(1): 146–148. DOI: 10.3201/eid2001.131071

Murillo J., Bofill L.M, Bolivar H., Torres C., Urbina J.A, Benhayon D., et al. Congenital Chagas’ disease transmission in the United States: Diagnosis in adulthood. ID Cases. 2016; 5: 72-75. DOI: https://doi.org/10.1016/j.idcr.2016.07.011

Castro-Sesquen Y.E, Gilman R.H, Galdos Cardenas G, Ferrufino L., Sánchez G., Valencia-Ayala E. Use of a Novel Chagas Urine Nanoparticle Test (Chunap) for Diagnosis of Congenital Chagas Disease. Plos Negl Dis. 2014; 8(10): e3211. DOI: 10.1371/journal.pntd.0003211

Klein M.D, Tinajeros F., Menduiña M.C, Málaga E., Condori B.J, Verástegui M. Risk factors of maternal Chagas Disease and vertical transmission in a Bolivian Hospital. Clin Infect Dis. 2021; 2450-2456. DOI: 10.1093/cid/ciaa1885

Viettri M., Lares M., Medina M., Herrera L., Ferrer E. Evaluation of commercial kits for the immunological and molecular diagnosis of Chagas disease in endemic areas of Venezuela. Enfermedades infecciosas y microbiología clínica. 2021. DOI: https://doi.org/10.1016/j.eimce.2021.11.002

Fumadó V., Juncosa T., Posada E., Fisa R., Gállego M., Gascón J. Chagas pediátrico en zona no endémica. Enfermedades Infecciosas y Microbiología Clínica. 2014; 32(5): 293-296. DOI: https://doi.org/10.1016/j.eimc.2013.04.024

Besuschio S.A, Picado A., Muñoz Calderón A., Weherendt D.P, Fernández M., Benatar A., et al. Trypanosoma cruzi loop-mediated isothermal amplification (Trypanosoma cruzi Loopamp) kit for detection of congenital, acute and Chagas disease reactivation. Plos Negl Trop Dis. 2020; 14(8): e0008402. DOI: 10.1371/journal.pntd.0008402

Campos-Valdez G., Canseco-Ávila L.M, González-Noriega F., Alfaro-Zebadua O., Nava-Medecigo I.Y, Jiménez-Cardoso E. Transmisión materno-fetal de Trypanosoma cruzi, un problema de salud poco estudiado en México: caso Chiapas. Salud Pública Mex. 2016; 58(3). DOI: https://doi.org/10.21149/spm.v58i3.7898

Bisio M.C, Rivero R., González N., Ballering G., D’Amico I., Kessler C., et al. Diagnostic Accuracy of Two Molecular Tools for Diagnosis of Congenital Chagas Disease. Molecular Diagnosis & Therapy. 2021; 25:791-801. DOI: https://doi.org/10.1007/s40291-021-00553-3

Denegri M., Oyarce A., Larraguibel P., Ramírez I., Rivas E., Arellano G., Báez A., et al. Cribado y transmisión congénita de la enfermedad de Chagas en población usuaria del Hospital Dr. Félix Bulnes Cerda y Atención Primaria de Salud del Servicio de Salud Metropolitano Occidente de Santiago, Chile. Rev. Chil. Infectol. 2020; 37(2). DOI: http://dx.doi.org/10.4067/s0716-10182020000200129

González L.F, Gastañaga-Holguera T., Jiménez-Montero B., Pérez Z.D, Ramos M.I, Amador P.M, et al. Seroprevalencia y transmisión vertical de enfermedad de Chagas en una cohorte de gestantes latinoamericanas en un hospital terciario de Madrid. Anales de Pediatría. 2018; 88(3): 122-126. DOI: https://doi.org/10.1016/j.anpedi.2017.03.003

Simón M., Gil-Gallardo L.J, Iborra M.A, Carrillero B., López M.C, Barja M.R, et al. An observational longitudinal study to evaluate tools and strategies available for the diagnosis of Congenital Chagas Disease in a non-endemic country. Acta trópica. 2019;199: 105127. DOI: https://doi.org/10.1016/j.actatropica.2019.105127

Cura C.I, Ramírez J.C, Rodríguez M., López-Albízu C., Irazu L., Scollo K., et al. Comparative Study and Analytical Verification of PCR Methods for the Diagnosis of Congenital Chagas Disease. The Journal of Molecular Diagnostics. 2017; 19(5): 673-681. DOI: https://doi.org/10.1016/j.jmoldx.2017.05.010

Velásquez E.B, Rivero R., De Rissio A.M, Malagrimo N., Esteva M.I, Riarte A.R, et al. Predictive role of polymerase chain reaction in the early diagnosis of congenital Trypanosoma cruzi infection. Acta Tropica. 2014; 137:195-200. DOI: https://doi.org/10.1016/j.actatropica.2014.05.016

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2023-06-29 — Updated on 2023-08-02

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Torres Martínez, D. S., Quimbaya Ramírez, J. J., & Monroy-Díaz, Ángela L. (2023). Diagnosis of congenital Chagas disease: Relevant aspects. Revista Médica De Risaralda, 29(1). https://doi.org/10.22517/25395203.25093 (Original work published June 29, 2023)

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Scoping Review