This is an outdated version published on 2023-06-29. Read the most recent version.

Adjuvant radiotherapy controversies in localized prostate cancer


Authors

  • Leandro Ricagni-Zabalveytia Universidad de la República
  • Milexys Rivero Fuentes Clínica San Rafael, Pereira
  • Federico Lorenzo-Gutiérrez Universidad de la República
  • Levin Martínez Hospital de Clínicas
  • Gabriel David Krygier-Waltier Hospital de Clínicas
  • Aldo Quartenti Universidad de la República

DOI:

https://doi.org/10.22517/25395203.25098

Keywords:

Radiotherapy, adjuvant, Prostate Cancer, prostatectomy.

Abstract

The choice of the most appropriate moment to perform radiotherapy in the treatment of prostate cancer is controversial since it can be performed immediately after prostatectomy or as rescue treatment in case of relapse. In this article, a search for the topic is carried out, the clinical trials with the best evidence are selected and the results are analyzed. Although there is benefit in adjuvant radiotherapy, this result is not found in all patients and it is associated with greater late genitourinary toxicity, therefore, the key is in the selection of treatment according to the specific patient.

Downloads

Download data is not yet available.

Author Biographies

Leandro Ricagni-Zabalveytia, Universidad de la República

Médico

Especilaista en Oncología Radioterápica

M.Sc. Radioterapia Avanzada

Milexys Rivero Fuentes, Clínica San Rafael, Pereira

Médica

Especialista en Oncología Radioterápica

Federico Lorenzo-Gutiérrez, Universidad de la República

Médico

Especialista en Oncología Radioterápica

Levin Martínez, Hospital de Clínicas

Médico

Especialista en Urología

M.Sc. Uro Oncología

Gabriel David Krygier-Waltier, Hospital de Clínicas

Médico

Especialista en Oncología Clínica

Aldo Quartenti, Universidad de la República

Profesor

References

Pisansky TM, Thompson IM, Valicenti RK, D’Amico AV, Selvarajah S. Adjuvant and salvage radiation therapy after prostatectomy: ASTRO/AUA guideline amendment, executive summary 2018. Pract Radiat Oncol. 2019; 9: 208–13.

Thompson I. M., Tangen C. M., Paradelo J., Lucia M. S., Miller G., Troyer D., et al. Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial. The Journal of urology. 2019;181(3): 956–962.

Bolla M., van Poppel H., Tombal B., Vekemans K., Da Pozzo L., de Reijke T. M., et al. Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911). Lancet. 2012; 380(9858): 2018–2027.

Wiegel T., Bartkowiak D., Bottke D., Bronner C., Steiner U., Siegmann A., et al. Adjuvant radiotherapy versus wait-and-see after radical prostatectomy: 10-year follow-up of the ARO 96-02/AUO AP 09/95 trial. European urology. 2014; 66(2): 243–250.

Tendulkar R. D., Agrawal S., Gao T., Efstathiou J. A., Pisansky T. M., Michalski J. M., et al. Contemporary Update of a Multi-Institutional Predictive Nomogram for Salvage Radiotherapy After Radical Prostatectomy. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2016; 34(30): 3648–3654.

Kneebone A., Fraser-Browne C., Duchesne G. M., Fisher R., Frydenberg M., Herschtal A., et al. Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non-inferiority trial. The Lancet. Oncology. 2020; 21(10): 1331–1340.

Sargos P., Chabaud S., Latorzeff I., Magné N., Benyoucef A., Supiot S., et al. Adjuvant radiotherapy versus early salvage radiotherapy plus short-term androgen deprivation therapy in men with localised prostate cancer after radical prostatectomy (GETUG-AFU 17): a randomised, phase 3 trial. The Lancet. Oncology 2020; 21(10): 1341–1352.

Parker C. C., Clarke N. W., Cook A. D., Kynaston H. G., Petersen P. M., Catton C., et al. Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial. Lancet. 2020; 396(10260): 1413–1421.

Tilki D., Chen M., Wu J., Huland H., Graefen M., Wiegel T., et al. Adjuvant Versus Early Salvage Radiation Therapy for Men at High Risk for Recurrence Following Radical Prostatectomy for Prostate Cancer and the Risk of Death. Journal of Clinical Oncology. 2021; 39:20: 2284-2293.

Abdollah F., Karnes R. J., Suardi N., Cozzarini C., Gandaglia G., Fossati N., et al. Impact of adjuvant radiotherapy on survival of patients with node-positive prostate cancer. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2014; 32(35): 3939–3947.

Jegadeesh N., Liu Y., Zhang C., Zhong J., Cassidy R. J., Gillespie T., et al. The role of adjuvant radiotherapy in pathologically lymph node-positive prostate cancer. Cancer. 2017; 123(3): 512–520.

Abdollah F., Dalela D., Sood A., Montorsi F., Peabody J. O., Mani Menon M., et al. Impact of Adjuvant Radiotherapy in Node-positive Prostate Cancer Patients: The Importance of Patient Selection. Eur Urol Oncol. 2018; 74(3): 253-256.

Downloads

Published

2023-06-29

Versions

How to Cite

Ricagni-Zabalveytia, L., Rivero Fuentes, M., Lorenzo-Gutiérrez, F., Martínez, L., Krygier-Waltier, G. D., & Quartenti, A. (2023). Adjuvant radiotherapy controversies in localized prostate cancer. Revista Médica De Risaralda, 29(1). https://doi.org/10.22517/25395203.25098

Issue

Section

Scoping Review