Human Metapneumovirus: An Emerging Challenge for Public Health


Authors

DOI:

https://doi.org/10.22517/25395203.25767

Keywords:

Human metapneumovirus, Virus, Respiratory infection

Abstract

Human metapneumovirus (hMPV) is a negative-sense single-stranded RNA virus, discovered in 2001, that belongs to the Paramyxoviridae family. This respiratory pathogen causes acute infections in individuals of all ages, being potentially severe in children, the elderly, and immunocompromised individuals. The epidemiology of hMPV shows seasonal prevalence, distributed globally, often coexisting with other respiratory viruses. The pathogenesis of hMPV involves the infection of epithelial cells in the lower respiratory tract, leading to symptoms ranging from mild colds to severe bronchiolitis and pneumonia. Clinical manifestations include fever, cough, wheezing, and dyspnea. Diagnosis is made using methods such as polymerase chain reaction (PCR) and rapid antigen tests. As for treatment, there is no specific antiviral; symptoms are managed with respiratory support and fluids. Prevention relies on hygiene measures, such as handwashing and avoiding close contact with infected individuals, with no vaccines currently available.

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Author Biography

Cristihian Gabriel Marin Ortega, Hospital Dr. Domingo Guzmán Lander

Internal Medicine Specialist. Hospital Dr. Domingo Guzmán Lander; Barcelona, Anzoátegui, Venezuela.

References

Sonja T, Jesse J, et al. Zoonotic origins of human metapneumovirus: a journey from birds to humans. Viruses. 2022;14(4):677. https://doi.org/10.3390/v14040677

Çetiner S, et al. Human metapneumovirus pneumonia during the SARS-CoV-2 pandemic. DAHUDER Med J. 2022;2(4):124–7. https://doi.org/10.56016/dahudermj.1167707

Russell CJ, et al. Human metapneumovirus: a largely unrecognized threat to human health. Pathogens. 2020;9(2):109. https://doi.org/10.3390/pathogens9020109

Esposito S, Mastrolia MV. Metapneumovirus infections and respiratory complications. Semin Respir Crit Care Med. 2016;37(4):512–21. https://doi.org/10.1055/s-0036-1584800

Reina J, Murillas J, Taboada C. Infección respiratoria aguda causada por el metapneumovirus humano: análisis de 39 casos. Med Clin (Barc). 2016;147(9):418–9. https://doi.org/10.1016/j.medcli.2016.05.004

Philippot Q, et al. Human metapneumovirus infection is associated with a substantial morbidity and mortality burden in adult inpatients. Heliyon. 2024;10(13):e33231. https://doi.org/10.1016/j.heliyon.2024.e33231

Holzemer NF, et al. Human metapneumovirus infection in hospitalized children. Respir Care. 2020;65(5):650–7. https://doi.org/10.4187/respcare.07156

Soto JA, et al. Human metapneumovirus: mechanisms and molecular targets used by the virus to avoid the immune system. Front Immunol. 2018;9:2466. https://doi.org/10.3389/fimmu.2018.02466

Cifuentes-Muñoz N, et al. Human metapneumovirus induces formation of inclusion bodies for efficient genome replication and transcription. J Virol. 2017;91(24):e01282-17. https://doi.org/10.1128/jvi.01282-17

Kroll JL, Weinberg A. Human metapneumovirus. Semin Respir Crit Care Med. 2011;32(4):447–53. https://doi.org/10.1055/s-0031-1283284

Wei TL, et al. Whole genome sequencing and evolution analyses of human metapneumovirus. Virus Genes. 2023;1–8. https://doi.org/10.1007/s11262-023-02001-2

Kamau E, et al. Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia. BMC Genomics. 2020;21(1):5. https://doi.org/10.1186/s12864-019-6400-z

Céspedes P, et al. Modulation of host immunity by the human metapneumovirus. Clin Microbiol Rev. 2016;29(4):795–818. https://doi.org/10.1128/CMR.00009-16

Skiadopoulos MH, et al. The two major human metapneumovirus genetic lineages are highly related antigenically, and the fusion (F) protein is a major contributor to this antigenic relatedness. J Virol. 2004;78(13):6927–37. https://doi.org/10.1128/JVI.78.13.6927-6937.2004

Wen X, et al. A chimeric pneumovirus fusion protein carrying neutralizing epitopes of both MPV and RSV. PLoS One. 2016;11(5):e0155917. https://doi.org/10.1371/journal.pone.0155917

Melero JA, Mas V. The Pneumovirinae fusion (F) protein: a common target for vaccines and antivirals. Virus Res. 2015;209:128–35. https://doi.org/10.1016/j.virusres.2015.02.006

Connolly SA, et al. Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy. Proc Natl Acad Sci U S A. 2006;103(47):17903–8. https://doi.org/10.1073/pnas.0607329103

Van den Hoogen BG, et al. Analysis of the genomic sequence of a human metapneumovirus. Virology. 2002;295(1):119–32. https://doi.org/10.1006/viro.2001.1355

Thompson RE, et al. Specific residues in the C-terminal domain of the human metapneumovirus phosphoprotein are indispensable for formation of viral replication centers and regulation of the function of the viral polymerase complex. J Virol. 2023;97(5):e0003023. https://doi.org/10.1128/jvi.00030-23

Loevenich S, et al. Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens. Front Immunol. 2023;14:1173605. https://doi.org/10.3389/fimmu.2023.1173605

Sojati J, et al. Clinical human metapneumovirus isolates show distinct pathogenesis and inflammatory profiles but similar CD8+ T cell impairment. mSphere. 2024;9(1):e0057023. https://doi.org/10.1128/msphere.00570-23

Bugatti A, et al. Human metapneumovirus establishes persistent infection in lung microvascular endothelial cells and primes a Th2-skewed immune response. Microorganisms. 2020;8(6):824. https://doi.org/10.3390/microorganisms8060824

Ballegeer M, Saelens X. Cell-mediated responses to human metapneumovirus infection. Viruses. 2020;12(5):542. https://doi.org/10.3390/v12050542

Boivin G, et al. Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis. 2002;186(9):1330–4. https://doi.org/10.1086/344319

Williams JV. Human metapneumovirus: an important cause of respiratory disease in children and adults. Curr Infect Dis Rep. 2005;7(3):204–10. https://doi.org/10.1007/s11908-005-0036-7

Rechi Sierra K, Varela DC. Neumonía por metapneumovirus humano en adulto con diabetes mellitus tipo 2. Rev Med Hondur. 2023;91(Suppl 1):S14. https://doi.org/10.5377/rmh.v91isupl.1.16176

Khan A, et al. Demographics, clinical presentation and outcome of metapneumovirus infection in adults: a case series analysis at Scarborough General Hospital, United Kingdom. Cureus. 2024;16(11):e73292. https://doi.org/10.7759/cureus.73292

Du Y, Liu X, et al. Rapid and one-tube detection of human metapneumovirus using the RT-RPA and CRISPR/Cas12a. J Virol Methods. 2024;315:115001. https://doi.org/10.1016/j.jviromet.2024.115001

Yajima T, et al. Comparison of sputum specimens and nasopharyngeal swab specimens for diagnosis of acute human metapneumovirus-related lower respiratory tract infections in adults. J Clin Virol. 2022;154:105238. https://doi.org/10.1016/j.jcv.2022.105238

Sugimoto S, et al. Development of a duplex real-time RT-PCR assay for the detection and identification of two subgroups of human metapneumovirus in a single tube. J Virol Methods. 2023;316:114812. https://doi.org/10.1016/j.jviromet.2023.114812

Freymuth F. Virus respiratorio sincitial, metapneumovirus y virus parainfluenza humanos: cuadro clínico y fisiopatología. EMC Pediatr. 2007;42(4):1–9. https://doi.org/10.1016/s1245-1789(07)70240-8

Alves MA, Borges SB, et al. Epidemiological profile of hospitalized human metapneumovirus in a capital of central-west of Brazil from 2017 to 2019: high lethality at extremes of age. Rev Patol Trop. 2023;51(4):243–53. https://doi.org/10.5216/rpt.v51i4.74236

Samuel S, et al. Human metapneumovirus infection in immunocompromised patients. Cancer Control. 2016;23(4):442–5. https://doi.org/10.1177/107327481602300416

Von Itzstein M, et al. Drug repurposing for therapeutic discovery against human metapneumovirus infection. bioRxiv. 2022. https://doi.org/10.1101/2022.07.24.501068

Van Den Bergh A, et al. Drug repurposing for therapeutic discovery against human metapneumovirus infection. Antimicrob Agents Chemother. 2022;66(10):e01008-22. https://doi.org/10.1128/aac.01008-22

Kumar P, Srivastava M. Prophylactic and therapeutic approaches for human metapneumovirus. VirusDis. 2018;29(4):434–44. https://doi.org/10.1007/s13337-018-0498-5

Wen SC, Williams JV. New approaches for immunization and therapy against human metapneumovirus. Clin Vaccine Immunol. 2015;22(8):858–66. https://doi.org/10.1128/CVI.00230-15

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Published

2025-09-22

How to Cite

Marin Ortega, C. G. (2025). Human Metapneumovirus: An Emerging Challenge for Public Health. Revista Médica De Risaralda, 31(2), 131–141. https://doi.org/10.22517/25395203.25767

Issue

Vol. 31 No. 2 (2025): July–December 2025

Section

Artículo de reflexión

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